Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
High fever Excessive night sweats Extreme fatigue Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
Severe swelling in lymph nodes (especially in the neck) CT scan abnormalities indicating TB inflammation Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
Severe chills and fever Uncontrollable night sweats Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
High-dose intravenous (IV) steroids for five days to calm the immune system A slow transition to oral steroids for three months Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot. Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications. Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
Myocarditis (heart muscle inflammation) Pericarditis (inflammation around the heart lining) Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
My Stepmom Burnt My College Acceptance Letter in a Fireplace — But She Wasn’t Smiling When a Stranger Showed Up at Our Door
When my stepmom burnt my college acceptance letter in the fireplace, I thought my dreams were gone. But then a stranger showed up at our door, holding a pink suitcase and a message from my late mother that changed everything.
This happened when I was 18, but I remember every detail like it was yesterday. It was the moment my life changed and I learned how strong I really was.
It was a warm April afternoon in the early 2000s, one of those Southern days when the sun feels like it’s going to melt your skin.
Sunny day in a town | Source: Midjourney
I was walking home from the animal shelter where I volunteered, clutching a bag of treats for Buster, my grumpy ginger cat. He was my comfort, my companion, and the one constant I could rely on in a life that often felt overwhelmingly lonely.
When I was a child, my mother passed away, leaving my dad and me to figure out life together. For a while, it felt like we were a team until he remarried Kelly. She never liked me and made sure I knew it.
Woman with arms crossed and a serious face in a living room | Source: Midjourney
From the beginning, she seemed to resent me, as if I was some competition for my dad’s love. After he tragically passed away in a car accident just after my 17th birthday, Kelly became my only guardian.
No extended family stepped in. No friends of my parents. It was just me and her. In a sense, I was grateful that I hadn’t been taken away to a group home. But she still didn’t like me.
18 year old woman looking sad in a living room with a blonde woman behind her | Source: Midjourney
Walking up the driveway, I shook off the heaviness that thinking about her always brought. I focused instead on the dream that had kept me going through all of her jabs, her undermining, and her disdain: college.
Today, I was supposed to get my acceptance letter. My escape plan was finally becoming real.
But as I opened the front door, a wave of heat slammed into me. It made no sense. It was spring in the South! The air outside was already hot, but inside, it felt like a sauna.
Wave of heat from a living room fireplace | Source: Midjourney
The sound of crackling fire drew my attention to the living room. I dropped my bag on the floor and stood frozen in the doorway, watching Kelly, who was perched by the roaring fireplace, staring into the flames, fixated.
“Kelly,” I asked cautiously, “why’s the fireplace on?”
She didn’t even turn to look at me. Instead, she smiled a cold, sharp smirk that made my stomach twist. “Oh, don’t worry, dear. I just thought you should see your college dreams go up in flames.”
Woman kneeling by a fireplace smiling evilly | Source: Midjourney
My breath caught in my throat. “What?” I croaked as I moved closer.
She gestured lazily at the fire, where I could see the remains of what looked like a large envelope and crisp papers reduced to ash.
“Your acceptance letter came,” she said casually, “but you don’t need it. You’ll be working at my café this summer and for the foreseeable future to thank me for being such a great stepmother. College isn’t in the cards for someone like you.”
For a moment, I couldn’t breathe, and the room blurred as tears welled up in my eyes.
18 year old woman looking horrified in a living room | Source: Midjourney
My escape plan, the life I had worked so hard to build for myself, had just been incinerated before my eyes. “Why would you do this?” I managed to whisper.
Kelly shrugged. “I’m doing you a favor, Pamela. You’d never make it in college anyway. It’s better for you to stick to practical work.”
I wanted to scream, to throw something, to demand she explain how she could be so cruel. But wait, maybe I could call the school? But the sharp ring of the doorbell cut through all my thoughts.
Man ringing a doorbell with his finger | Source: Midjourney
Kelly frowned and stood up, smoothing down her sweater. “Stay here,” she snapped. “I’ll get it.”
Wiping at my cheeks, I followed her to the door, though I didn’t have the energy to argue. I assumed it was one of our neighbors, here to chat or drop something off.
But when she opened the door, it wasn’t a familiar face. Standing on the porch was a distinguished-looking man in a crisp suit, holding a bright pink suitcase.
Man in a grey suit on a porch with a pink suitcase | Source: Midjourney
“Are you Pamela?” he asked, his eyes meeting mine with warmth.
“Yes,” I said cautiously, stepping forward.
“I’m Mr. Robertson,” he said, holding out his hand to me. “I’m here because your mom asked me to.”
I blinked. “My mom?” The words felt foreign in my mouth. I barely remembered her. “I don’t understand.”
18 year old woman surprised in a doorway of a house | Source: Midjourney
Mr. Robertson nodded as if he’d expected my confusion. “Your mother and I knew each other when we were students at the state college. We stayed in touch over the years, and she always spoke about you with such love and hope for your future. I’m now the Dean of Admissions. When I saw your application come through, I knew I had to ensure her dream for you became a reality.”
Two students on a college campus | Source: Midjourney
I glanced at Kelly, whose face turned a shade of red I’d never seen before. She was about to explode. “This is highly inappropriate,” she sputtered, stepping forward. “I should call the school to report you for intervening in admissions. Besides, Pamela is busy this summer. She has obligations. She won’t be going—”
A woman looking upset in the doorway of a house | Source: Midjourney
Mr. Robertson held up a hand, silencing her with one look. “Ma’am, I understand your concerns, but Pamela’s acceptance to the college is well-deserved. She has exceptional qualifications and wrote an essay that moved the admissions committee deeply. She’s earned this opportunity,” he stated seriously. “I just wanted to meet her and make sure she knows it.”
Man with a serious expression in the doorway of a house | Source: Midjourney
My throat tightened with his words, but breathing became even harder when he pulled a worn photograph from his suitcase. It was my mother, young and vibrant, smiling in her graduation cap and gown. Standing beside her was a much younger Mr. Robertson.
“Your mom always wanted this for you,” he said, handing me the photo. “And she would be so proud of you.”
For a moment, I couldn’t speak. The weight of everything, the loss of my mom, the grief for my dad, and the years of enduring Kelly’s belittling, overwhelmed me. But alongside the sadness, I felt something else: hope.
18 year old woman smiling in the doorway of a house | Source: Midjourney
Mr. Robertson continued, “Obviously, your classes don’t start until September, but I’d like to offer you a summer internship in my office after your graduation. It’s just admin work, but it’ll give you a chance to familiarize yourself with the campus, earn some money, and get a head start.”
“She can’t go!” Kelly snapped, shrilly. “She has to work at the café all summer. We’re much too busy! Besides, I burned her acceptance letter already!”
Woman yelling angrily in the doorway of a house | Source: Midjourney
Something inside me surged. For one second, after seeing my future burning in that fireplace, I had given up. Mr. Robertson had come just at the right time, like a message from my mom—an angel.
So, I turned to her, wiping my tears. “No, Kelly,” I said, breathless but resolute. “I’m not a child. You can’t control me anymore. I let you, but I shouldn’t have, not since I turned 18. Even if Mr. Robertson hadn’t arrived, I would’ve called the school to explain. I AM going to college, no matter what you do.”
18 year old woman looking determined in the doorway of a house | Source: Midjourney
She opened her mouth to argue, but Mr. Robertson stepped in, reaching inside his pink suitcase again and producing an envelope. “Ma’am, I have a copy of her acceptance. Pamela deserves this opportunity. She earned it,” he said. “If you interfere, I’ll be forced to take further action.”
“But she owes me,” Kelly insisted, her features twisting.
“No, I don’t,” I retorted, feeling the truth of those words fully. I don’t think I could’ve uttered them earlier or without Mr. Robertson by my side.
18 year old woman smiling in the doorway of a house | Source: Midjourney
Kelly glared at us, but the fight quickly went out of her. She turned on her heel and stormed away from the open front door into her bedroom.
I focused back on Mr. Robertson, who handed me his business card. “Call me later so we can finalize the details, so you’ll be ready after you finish high school,” he said. “Your mother would be so proud of you. Never forget that.”
I nodded, smiling brightly at my savior, who returned my grin.
Man smiling in the doorway of a house | Source: Midjourney
As he walked away, I stood on the porch, holding tightly to the photo, his card, and the copy of my acceptance letter. The three items that proved I was not only free but also not so alone.
That night, I packed a bag. Then, working up the courage, I called my friend Sarah, who told me to come live with her and her parents. Before, she’d been just a school companion, but from that moment on, she became family.
I moved out of Kelly’s house the next day with my cat, leaving behind my stepmother’s toxic grip for good.
Ginger cat in a woman’s arms | Source: Midjourney
Over the next few weeks, I finished high school happily, knowing that a brighter future awaited me. By early June, I started my internship and loved every minute, although it was mostly menial work.
Despite my pay, I had to take out some student loans. However, Mr. Robertson helped me apply for scholarships whenever he found any.
Unfortunately, I couldn’t live in the dorms with Buster, but I found pet-friendly student housing nearby.
Ginger cat with woman in the background | Source: Midjourney
The rest is history. It’s been around 20 years, and I have a family now, a solid career, and more happiness than I could hope for. Buster died a few years ago. He was my soul cat, but we now have 3 more kitties to adore.
Sarah is still very much in my life, too.
I don’t know what happened to Kelly. I didn’t bother to keep in touch with her. But I learned something from her that I’ve never forgotten. There will always be people who try to put you down, extinguish your light, and force you to become someone you’re not.
Happy woman with arms up outdoors | Source: Midjourney
You can’t give up when that happens. Instead, you need to rise. Fight for your dreams and shine brightly, because you are capable of so much more than they can imagine.
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