The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
5+ Astonishing Things That Make Curvy Women Absolutely Irresistible to Men
Men really like plus-size women, and they openly talk about why they like them on social media. It’s not only about their bodies, though. Curvy women can capture their hearts with their self-assurance, charm, and irresistible appeal. Their curves are just a bonus that makes them even more attractive.
1. Their hugs are truly amazing.
One thing that stands out is snuggling. Many men enjoy cuddling with their partners, and curvy girls have an advantage in this area. One man said, “I like bigger women for the same reason I like my body pillow more than my regular pillow.”
2. Positivity comes naturally to them.
Curvy girls are never boring to be around because of their positive, fun, and kind personalities, which are also quite interesting. They love to chat and keep the relationship lively. It’s these qualities that make them truly special.
3. Dining with a curvaceous woman brings much joy and pleasure.
A man explained, “Eating is one of life’s great pleasures. It’s one of the best things to do on a date. It’s one of the best relationship activities after you’re married.” He agrees that occasionally following a diet is essential for maintaining good health if it’s a priority for you. However, it shouldn’t become your main focus in life.
4. Their confidence is unmatched.
Men have noticed two important qualities in curvy women that they really like. The first quality is their ability to handle difficult situations. Through challenging experiences, they have developed confidence and learned to accept and appreciate themselves just as they are.
5. They are incredibly nurturing and compassionate.
In general, bigger women have exceptional nurturing qualities. Men see them as more caring and loving, always putting the needs of others first. Additionally, curvy women really enjoy spending quality time with their partners. They find joy in even the simplest things, like cooking together, playing, laughing, and having deep, meaningful conversations.
6. Their figures are adored by men everywhere.
Men are naturally attracted to women who have curvier bodies because they find their physical features appealing. They particularly like well-defined thighs and hips, which are the qualities they look for in a partner. They find the curvier features attractive and intriguing.
Women are gorgeous just like they are, with all their unique body shapes. They deserve to be loved for who they are beyond superficial judgments. In today’s world of social media, where beauty standards are forced upon us, it can negatively impact those who struggle with self-confidence. It’s crucial to remember that our differences are what truly make us beautiful.
Preview photo credit ashleygraham / Instagram, ashleygraham / Instagram
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