The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Everyone was wondering what happened to Carrie Underwood’s husband
A regular pair on the red carpet is Carrie Underwood and her spouse, Mike Fisher. At the most renowned award shows in the world, such as the Grammys, CMA Awards, and American Music Awards, they have walked together.
Usually, we can’t get enough of how adorable this country music artist and her retired hockey player spouse are together.
One place you can always be sure to see Fisher standing proudly by his wife’s side is the CMT Music Awards. The former star player for the Nashville Predators made appearances with Underwood in the following seasons: 2012, 2013, 2014, 2015, 2016, 2018, and 2019.
Following the outbreak, award shows saw a minor change in operation, but Fisher rejoined his wonderful wife in 2022.
On April 2, however, when the 2023 CMT Awards took place in Austin, Texas, Fisher was nowhere to be seen. What’s the deal, then?
Regarding Mike Fisher and Carrie Underwood, don’t assume that there is conflict in paradise. Since his wife was vying for both Female Video of the Year and Video of the Year at the 2023 CMT Awards, he chose not to attend in person to support her.
The “Hate My Heart” singer admitted on the red carpet that her hubby was really on dad duty for the evening when asked where he was.
“My spouse is in command of the children. Usually, he holds down the fort while I work on projects like these. Even at home, she seemed to be watching her three boys since she shouted out to them. Oh no!
Notably, the former hockey great most likely did not have as much access to the 2023 award ceremony as he did in previous years. Nashville, the home of country music, has hosted the CMTs in recent years.
This happened close to Franklin, Underwood and Fisher’s home in a Nashville suburb. Nevertheless, the award ceremony was set to move to Texas in November 2022.
Underwood looked as like she was making the most of her time in Texas, far from her sons, though, as she looked stunning in a two-piece made of rhinestones that would have put her on any Best Dressed list.
Despite being well-known, Carrie Underwood and Mike Fisher make an effort to keep their two kids, Isaiah and Jacob, out of the spotlight. The singer of “Jesus Take the Wheel” and Fisher made the decision not to bring the kids along on tour last year in order to prevent upsetting their routine.
Underwood told ET Canada, “They are not coming with me this time.” “We prioritize my oldest’s education, and she is enrolled in school. We desire for their lives to be as typical as they may be.
Underwood added that Fisher is a hands-on father, which frees her up to focus on her career. I consider myself fortunate as well. I must boast a little about my husband,” she murmured. “He’s got it. He has it under lock and key while I’m not here. I never have to worry about dirty laundry or unpacked lunches.
And considering Fisher’s desire to have a child, that makes sense. He expressed his excitement about becoming a father to The Tennessean prior to Isaiah’s birth in 2015.
“Many people say it’s impossible to explain until it happens, and then it’s the greatest thing ever,” he said about having children. “I’m simply considering how to be the greatest father I can be.”
Although Mike Fisher and Carrie Underwood seem like the perfect couple right now, this wasn’t always the case. Fisher has always wanted to be a loving mother, but Underwood first had doubts about her capacity to be a decent mother.
In the “Mike and Carrie: God & Country” documentary, the country music star said, “I’ve never been fantastic with other people’s children. “Why would I be terrific with one of my own?” She also mentioned that initially, starting a family wasn’t even on her list of priorities.
She said, “I don’t think I ever thought about getting married or starting a family.” “I’m a good solo performer.” Conversely, Fisher was the complete opposite.
Along with my three other siblings, I was raised. In addition, my parents were amazing. And I think all I wanted was something similar,” he said. “I wanted to have a wife like my mother, to be like my father, and to be the best father I could be. and while residing in the nation, bear children.
Nevertheless, everything turned out for the best because Underwood and Fisher and their two kids now reside in the country. Underwood’s whole outlook on parenthood was completely upended after Isaiah was born. It has altered who I am as a person. I feel better now. Most of the time, I’m in a better mood,” she said in an interview with Redbook Mag. “I am completely enamored!”
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