The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
After Treat Williams’ untimely departure, Catherine Zeta-Jones and John Travolta lead heartfelt tributes to him
Actor Address Williams tragically passed away after a horrific motorcycle accident, and numerous celebs sent their condolences to his family via social media.
The 71-year-old calendar man passed away as a consequence of the party, according to a statement released by his agent Barry McPherson on Monday, June 13.
John Travolta, who reminisced their Broadway adventures in the musicals Grease and More Than Here, was among the first to pay their respects to the late actor.
He recalls, “Treat Williams and I started together in NYC by appearing in two Broadway productions, More than Below and Grease.”
“I’m really sorry, treat. You and your family are on my mind. You’ll be missed by us. Greetings, John.
The Phantom, a 1996 movie starring Williams and Catherine Zeta-Jones, was tweeted with the simple message “R.I.P. Dearest Handle Williams.” Zeta-Jones shared a still from the movie.
Kim Cattrall, an actress and mother of two who costarred with the late actor in the 1999 television movie 36 Hours to Die, tweeted, “I’m in shock!”
“Farewell, Pricey Ensure. My sympathies go out to Pam, Gille, Ellie, and the family. a fantastic actor and friend.
“Sad information, relax in peace, brother,” Sharon Stone tweeted beside a screenshot of a news article claiming his death.
Mark Hamill shared a picture of them from the established with the caption, “Just got the terrible news that the globe has missing @Rtreatwilliams.” Mark Hamill was an uncredited storm base warrior with him in The Empire Strikes Back (1980). Such a wonderful individual, such a skilled actor, and such a cherished close friend. It breaks my heart. #RIP_Pal.”
“The numerous instances we worked collectively was generally remarkable and I was usually enthusiastic for the next time,” stated Emily VanCamp, the actress who portrayed Williams’ co-star in the film Everwood, with a picture of the actor in his youth. I’m offering my best wishes to your family, Deal with. Go get it, my dear friend.
“Treat and I spent months filming As soon as On a Time in America in Rome,” said James Woods, his co-star in the epic criminal offense drama from 1984.
“A long shoot can make traveling very lonely, but his constant sense of humor and amazing sense of humor have been invaluable. I’m saddened by his passing because he was someone I truly appreciated. #TreatWilliams, Godspeed.
Billy Baldwin penned a lengthy tribute to the celebrity in which he extolled his qualities as a clever, skillful, charming, witty, successful, attractive, and kind person. “Heart of gold.”
“A terrible loss,” he continued. He fought tirelessly to improve the climate and advance social fairness. We won’t get to see you. Manage your leisure time peacefully.
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